
This book examines the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. It highlights the initial stage of tumor metastasis.

Overview of Signal Transduction in Tumor Metastasis.- Microenvironment Triggers EMT, Migration and Invasion of Primary Tumor via Multiple Signal Pathways.- The ERK1/2 MAP Kinase Signaling Pathway in Tumor Progression and Metastasis.- Mitogen-Activated Protein Kinase-Activated...