Serotonin and Anxiety: Neuroanatomical, Pharmacological, and Functional Aspects

By Caio Maximino

Introduction and scope of the review.- Anxiety and risk assessment.- Fear/panic and the fight/flight/freeze system.- "Coping" styles, stress reactivity, and the active-passive continuum.- Serotonin in the nervous system of vertebrates.- Synthesis and metabolism of serotonin.- Transport of serotonin: SERT and uptake.- Serotonin receptors.- 5-HT1A receptors.- 5-HT1B receptors.- 5-HT2C receptors.- Nodal structures in anxiety-like and panic-like responses.- Nodal structures regulating anxiety: The behavioral inhibition system.- "Limbic" portions of the medial prefrontal cortex.- The extended amygdala.- The ventral hippocampus.- The lateral habenula.- Nodal structures regulating panic: The cerebral aversive system.- The central amygdala.- The medial hypothalamic defense system.- The mesopontine rostromedial tegmental nucleus.- The periaqueductal gray area.- Locus coeruleus.- The dual role hypothesis.- Destruction or blockade of DRN neurons is anxiolytic and panicogenic.- The defensive context for increased serotonin release.- Topographic organization of DRN. - The dorsal portion of the DRN is part of a mesocorticolimbic system involved in anxiety-like responses.- The caudal portion of the DRN is highly responsive to stress-related peptides.- The lateral wings of the DRN are involved in panic-like responses.- General conclusions.

• Format: Paperback
• Language: English
• ISBN: 1461440475
• ISBN13: 9781461440475
• Release Date: May 2012
• Publisher: Springer
• Length: 111 Pages
• Weight: 0.40 lbs.
• Dimensions: 0.3" x 6.0" x 9.0"