Senolytics in Disease, Ageing and Longevity

By Daniel Muñoz-Espin

Book Overview

Preface
Section-1 ORIGINS AND DEVELOPMENT OF SENOTHERAPIES
Chapter 1 Senolytic drug development
Chapter 2 Discovery of Senolytics and the pathway to early phase clinical trials

Section-2 THE IMPACT OF SENOTHERAPIES: FROM REGENERATION TO AGING
Chapter 3 Interconnection between cellular senescence, regeneration and ageing in salamanders
Chapter 4 Senolytics target senescent cells and improve aging and age-related diseases
Chapter 5 Senotherapy of cancer

Section-3 UNDERSTANDING AND TARGETING THE SENESCENT SURFACEOME
Chapter 6 Targeted senolytic strategies based on the senescent surfaceome
Chapter 7 Senolysis and senostasis through the plasma membrane

Section-4 NOVEL SENESCENCE-ASSOCIATED MARKERS AND TARGETS
Chapter 8 In situ detection of miRNAs in senescent cells in archival material
Chapter 9 Novel probes and carriers to target senescent cells
Chapter 10 Potential applications of aptamers for targeting senescent cells
Chapter 11 Mitochondria: potential targets for interventions to counteract senescence

• Format: Paperback
• Language: English
• ISBN: 303044905X
• ISBN13: 9783030449056
• Release Date: April 2021
• Publisher: Springer
• Length: 222 Pages
• Weight: 0.73 lbs.
• Dimensions: 0.5" x 6.1" x 9.2"