Sarcopenia - Age-Related Muscle Wasting and Weakness: Mechanisms and Treatments

Book Overview

1.Overview.- 2. Molecular mechanisms of muscle wasting in cancer and ageing: cachexia versus sarcopenia.- 3. Age-related remodeling of neuromuscular junctions.- 4.Motor unit remodeling during aging.- 5. Age-related decline in actomyosin structure and function.- 6. Excitation-contraction coupling in aged skeletal muscle.- 7. Mitochondrial function in aging skeletal muscle.- 8. Fibrosis and skeletal muscle aging.- 9. Nuclear apoptosis and sarcopenia.- 10. Age-related changes in the molecular regulation of skeletal muscle mass.- 11. Genetic variation and skeletal muscle traits: implications for sarcopenia.- 12. Proteomic profiling of aged skeletal muscle.- 13. Aging, exercise and muscle protein metabolism.- 14. Reactive oxygen species generation and skeletal muscle wasting - implications for sarcopenia.- 15. Exercise as a countermeasure for sarcopenia.- 16. Role of contraction-induced injury in age-related muscle wasting and weakness.- 17. Role of IGF-I signaling in age-related changes in skeletal muscle.- 18. Role of myostatin and TGF-beta signaling in skeletal muscle growth and development: implications for sarcopenia.- 19. β-Adrenergic signaling in sarcopenia and other muscle wasting disorders.

• Format: Paperback
• Language: English
• ISBN: 9400790449
• ISBN13: 9789400790445
• Release Date: November 2014
• Publisher: Springer
• Length: 479 Pages
• Weight: 1.52 lbs.
• Dimensions: 1.0" x 6.1" x 9.2"