Safety and Efficacy of Gene-Based Therapeutics for Inherited Disorders

Book Overview

Overview: gene transfer strategies, principles, applications.- Manufacturing viral gene therapy vectors: general approaches and challenges.- Retrovirus- and lentivirus-based vectors.- Preclinical and clinical applications of retroviral vectors.- Preclinical and clinical applications of lentiviral vectors.- Retrovirus and lentivirus integration.- Adenovirus-based vectors for gene therapy.- Adenoviral vector-host interactions.- Helper-dependent adenoviral vectors.- Gene therapy for cancer treatment.- Oncolytic adenoviruses for cancer treatment.- Vaccination by gene transfer vectors.- AAV vectors: general features and applications.- Adaptive immune response to viral vector delivery.- Herpes viruses: general features and applications.- RNA interference-based strategy for treatment of human diseases.- Antisense oligonucleotide based therapeutics.- Gene editing strategies.- Nonviral vectors.

• Format: Paperback
• Language: English
• ISBN: 3319851586
• ISBN13: 9783319851587
• Release Date: May 2018
• Publisher: Springer
• Length: 220 Pages
• Weight: 0.73 lbs.
• Dimensions: 0.5" x 6.1" x 9.2"