I. Long Term Health Consequences of Restless Legs Syndrome/Willis-Ekbom Disease1. Mental Health Disorders Associated with RLS2. Sleep Impact: Insomnia, Hypersomnia, Sleep Attacks, and Circadian Disorders3. Cognitive Functioning4. Health Related Quality of Life and Depression/Anxiety Symptom Measures for the Assessment of Treatment in Restless Legs Syndrome/Willis-Ekbom Disease 5. Epidemiologic Evidence in Cardiovascular Disease6. Heart Rate and Blood Pressure Changes Associated with Periodic Limb Movements7. Willis-Ekbom Disease, Periodic Limb Movements of Sleep, and Cardiovascular Disease: Putative Mechanisms and Implications for Long-Term Treatment8. Peripheral Muscle Changes 9. Outcome and Mortality in Renal Failure-Related RLS II. Long Term Management of Restless Legs Syndrome/Willis-Ekbom Disease10. Long Term Pharmacological Treatment 11. Augmentation: Criteria, Prevalence, and Differential Diagnosis12. Treatment Options When Short-Acting Dopamine Agonists Fail or Cause Augmentation: Switching or Adding Medications13. Management of Augmentation 14. Managing Concurrent Medications15. Impulsive Behaviors: Definition, Prevalence, Neurobiology, and Management 16. Impulse Control Behavior in Movement Disorders: Focus on Restless Leg Syndrome17. Management of RLS During Pregnancy18. Management of RLS in Children (Unique Features)
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