Resistance to Molecular Therapies for Hepatocellular Carcinoma

Book Overview

This volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment resistance in HCC patients, including components of the immune system and tumor microenvironment; determines the role of the cancer stem cell phenotype in resistance; reviews the experimental models to study resistance; and addresses new approaches to overcome resistance to sorafenib, using successful examples from other malignancies.

• Format: Hardcover
• Language: English
• ISBN: 3319561960
• ISBN13: 9783319561967
• Release Date: July 2017
• Publisher: Springer
• Length: 147 Pages
• Weight: 0.90 lbs.
• Dimensions: 0.4" x 6.1" x 9.2"