Protein Polyubiquitination&Oxidative Damage in Hepatic Encephalopathy

by Jasmin Klose

Hepatic encephalopathy (HE) is a common complication of cirrhosis. Hyperammonemia is considered a major factor contributing to the neurological deficit in HE. This study investigated the effect of hyperammonemia on protein oxidation and degradation in the hippocampus. Hyperammonemia was induced in mice by administration of ammonium. Hippocampal proteasome activity, protein oxidation and ubiquitination were analyzed. Expression and regulation of proteasome...

• Format: Paperback
• Language: English
• ISBN: 3838152956
• ISBN13: 9783838152950
• Release Date: October 2016
• Publisher: Sudwestdeutscher Verlag Fur Hochschulschrifte
• Length: 100 Pages
• Weight: 0.35 lbs.
• Dimensions: 0.2" x 6.0" x 9.0"