Protective Groups in Organic Synthesis

By Theodora W. Greene and Peter G.M. Wuts

Book Overview

From the reviews of the previous editions: * "For completeness, the authors . . . include protective groups and techniques for formation and cleavage that are seldom used as well as those that are more common. . . . Anyone who does organic synthesis must have convenient access to this book." -Journal of the American Chemical Society. * "Essential to the modern synthetic organic chemist . . . should be in the libraries of all academic, governmental, and industrial organizations concerned with organic synthesis." -Polymer News. Reflecting the latest advances in protective group methodology, this Third Edition of the proven laboratory reference is expanded by more than 50%, providing readers with a comprehensive compendium of 1,050 of the most useful protective groups as well as 5,350 references to original publications. Protective groups are organized by six major organic functional groups: hydroxyl, amino, carboxyl, carbonyl, sulfhydryl, and phosphate groups (the last new to this edition). Also added in this edition are protection of the alkyne-CH, expanded coverage of protection of all groups, and many new enzymatic methods of protection and deprotection. Each chapter briefly describes the classes of available protective groups, followed by an in-depth look at the chemistry of individual protective groups, their properties, and the best methods of formation and cleavage. Ten reactivity charts with more than 28,000 entries summarize the relative reactivities of 270 commonly used protective groups with 108 reagents. This book will be an indispensable reference for synthetic chemists and students.

• Format: Hardcover
• Language: English
• ISBN: 0471160199
• ISBN13: 9780471160199
• Release Date: April 1999
• Publisher: Wiley-Interscience
• Length: 816 Pages
• Weight: 2.94 lbs.
• Dimensions: 9.9" x 1.6" x 6.1"

Customer Reviews

A must have for any synthetic laboratory

There are other protecting group books out there but I found this one to be the most comprehensive and easy to use.

Essential

If you are a graduate student in organic chemistry then this book is a must. It will help with class work as well as your lab work. This book is the authority on protective groups and is an essential reference.

essential reference

Like every other edition of Greene's Protective Groups, this updated version is concise with reliable references and schematics. All researchers need this book.

Indispensible

Quite possibly the most important protecting group book published. The new edition is out and is even more extensive and completely up to date. However, "Greene and Wuts" is a bible in the laboratory. Many of you who will read this have probably scrambled for your copy of "Greene," as it is affectionately known, when designing a synthesis. Also check out Kocienski's protecting group book and his extensive reviews if you do not know about them.