Proteases: Structure and Function

Book Overview

1 Protease families, evolution and mechanisms of action "Set the stage".- 1.1 Enzyme families, prototypes and catalytic mechanisms.- 1.2 Enzyme kinetics, mathematical modelling and perspectives.- 1.3 Structure determination and search for inhibitors.- 2 Regulation of proteolysis "Positioning and teaming-up to control activity".- 2.1 Compartmentalization of proteolysis.- 2.2 Biosynthesis of lysosomal proteases.- 2.3 Interactions of proteases and inhibitors / networking in the degradome.- 2.4 In vivo analysis of the protease and inhibitors concert.- 3 Proteases in development "Born to be right".- 3.1 Proteases for pattern formation during morphogenesis.- 3.2 Proteases in death pathways (apoptosis, necrosis).- 4 Proteases in physiology and pathophysiology "Cleave to function in health or to cause disease".- 4.1 Protein turnover and signaling functions (degrade to rebuild, remodel, process and mature for signalling).- 4.2 Proteases in control of physiology.- 4.3 Cancer: invasion and metastasis.- 4.4 Bacterial proteases.- 4.5 Viral proteases.

• Format: Paperback
• Language: English
• ISBN: 3709119391
• ISBN13: 9783709119396
• Release Date: August 2016
• Publisher: Springer
• Length: 564 Pages
• Weight: 1.76 lbs.
• Dimensions: 1.2" x 6.1" x 9.2"