Description A comprehensive and practical guide strictly aligned with the Pharmacy Council of India (PCI) syllabus for B. Pharm Semester VI students (Course Code: BP607P). The 'Practical Manual of Medicinal Chemistry - III' bridges the gap between theoretical drug design concepts and hands-on laboratory execution. Designed to meet the challenges of modern academic laboratories, this manual uniquely adapts classical synthetic procedures into a 'Semi-Micro Scale' (1.0 g model). This innovative approach not only minimizes chemical consumption and ecological hazards but also sharpens students' analytical weighing and handling skills, making it highly cost-effective for large student batches. Key Features of the Book: - Complete PCI Coverage: Step-by-step procedures for the synthesis of important drugs and intermediates including Sulphanilamide, Tolbutamide, Hexamine, and more. - Analytical Excellence: Detailed classical volumetric assay methods for crucial drugs like Isoniazid, Chloroquine, Dapsone, and Benzyl Penicillin. - Green Chemistry Integration: Modern Microwave-Assisted Organic Synthesis (MAOS) protocols for the rapid preparation of Benzimidazole, Phenytoin, and Dihydropyrimidine derivatives. - CADD Applications: Practical introduction to Computer-Aided Drug Design using open-source virtual lab platforms to compute ADME properties and evaluate Lipinski's Rule of Five. - Clear Formatting: Precisely formatted chemical equations, detailed mechanisms, scale-up tables, and Viva Voce questions to ensure complete academic clarity. Authored by an experienced Assistant Professor of Pharmaceutical Sciences, this manual is an indispensable tool for pharmacy students, educators, and laboratory instructors seeking a modern, eco-friendly, and precise approach to medicinal chemistry.
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