Polyomavirus nephritis

By Soumaya CHARGUI, David Buob, Meriam Khadhar

Polyomavirus nephritis (PVAN) is one of the most common viral complications in renal transplantation. It is in more than 97% of cases caused by BK virus in the context of BK virus nephritis and in less than 2% caused by JC virus. PVAN leads to graft loss in 30 to 80% of cases. Early diagnosis is therefore necessary to modify the immunosuppressive treatment and avoid graft loss. The diagnosis of PVAN is histological and combines tubulo-interstitial inflammation and a viral cytopathic effect in the form of nuclear inclusions of tubular cells. Tubular cell infection can be highlighted by immunohistochemical evidence of Sv-40 viral antigen expression. PVAN has histologic similarities to acute cellular rejection, but the resulting treatments are diametrically opposed. One requires a decrease in immunosuppression, while the other requires an increase in immunosuppression, so accurate and early diagnosis is a major challenge.

• Format: Paperback
• Language: English
• ISBN: 6205665581
• ISBN13: 9786205665589
• Release Date: February 2023
• Publisher: Our Knowledge Publishing
• Length: 52 Pages
• Weight: 0.20 lbs.
• Dimensions: 0.1" x 6.0" x 9.0"