Phosphodiesterases as Drug Targets

by Sharron H. Francis

Book Overview

Phosphodiesterase inhibitors: History of pharmacology; PDE inhibitors: factors that influence potency, selectivity and action; A fission yeast-based platform for phosphodiesterase inhibitor high throughput screening and analyses of phosphodiesterase activity; The pharmacokinetics of PDE inhibitors and the impact of this on their efficacy and the therapeutic window; Structural insight into the substrate specificity of phosphodiesterases; The GAF-tandem...

• Format: Paperback
• Language: English
• ISBN: 3642269451
• ISBN13: 9783642269455
• Release Date: November 2013
• Publisher: Springer
• Length: 522 Pages
• Weight: 1.65 lbs.
• Dimensions: 1.1" x 6.1" x 9.2"