Pharmacogenomics: Methods and Protocols

Book Overview

Expert researchers and physician/clinicians describe in detail the newest and most commonly used technologies today in this rapidly advancing field. The authors provide readily reproducible methods for assessing the functional consequences of a certain polymorphism, evaluate the variety of genotyping platforms currently available, and discuss the management of pharmacogenomic information. Highlights include techniques for making a snapshot of the allele-specific variation in human gene expression, genome wide analysis of allele-specific expression using oligo microarrays, in vivo assays with HaploChIP, SNP genotyping in DNA pools, and PharmGKB, the pharmacogenetics and pharmacogenomics knowledge base. The methodologies for genotyping include denaturing high-performance liquid chromarography, pyrosequencing, kinetic-fluorescence detection, mass spectrometry, and TaqMan assay for insertion/deletions.

• Format: Hardcover
• Language: English
• ISBN: 1588294404
• ISBN13: 9781588294401
• Release Date: August 2005
• Publisher: Humana
• Length: 214 Pages
• Weight: 1.07 lbs.
• Dimensions: 0.8" x 6.3" x 9.3"