Classifying different salivary gland neoplasms (SGNs) distinctly has always been challenging. The present review aims to elaborate on the classification of SGNs based on the concepts of histogenesis and morphogenesis. In tumor pathology, histogenesis corresponds to the origin of the neoplastic cells; whereas morphogenesis refers to the development of the shape of an organ. Our review elucidates the pathogenesis of the salivary gland tumor to understand the resulting histopathology, tumor morphology, and cellular differentiation of the tumor which reflects the parent cell. It comprehensively covers histogenesis, morphogenesis, and their relevance to the common salivary gland tumors, along with a brief account of the immunohistochemical markers.
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