Ovarian Cancer

By Brenton and James D Brenton

Epithelial ovarian cancer (EOC) is among the most lethal gynecologic malignancies, claiming lives worldwide. It is often diagnosed late, recurs frequently, and resists long-term control. Despite decades of progress in molecular profiling, targeted therapeutics, and detection technologies, the complexity of EOC continues to challenge clinicians and researchers.

This landmark volume brings together leaders in oncology, developmental biology, molecular pathology, and translational medicine to provide a comprehensive, integrated account of the biology, pathogenesis, prevention, detection, and treatment of ovarian cancer.

Highlights include:

A reframing of EOC's origins through insights from developmental biology and embryologyAnalyses of distinct histotypes--high-grade serous, low-grade serous, mucinous, and clear cell carcinomas--that reveal vulnerabilities and therapeutic opportunitiesAdvances in preclinical models, from engineered mice to organoidsExplorations of genomic instability, immune environments, and mutational processes that drive therapeutic resistanceUpdates on prevention, early detection, and systemic therapies, including immunotherapies
Ovarian cancer is not a single disease but a spectrum of distinct malignancies requiring tailored approaches. Ovarian Cancer is an essential reference volume for oncologists, biomedical researchers, and trainees that will assist the multidisciplinary collaborations necessary to improve patient outcomes.

• Format: Hardcover
• Language: English
• ISBN: 1621822354
• ISBN13: 9781621822356
• Release Date: June 2026
• Publisher: Cold Spring Harbor Laboratory Press
• Length: 250 Pages
• Weight: 1.55 lbs.
• Dimensions: 0.7" x 7.0" x 10.0"