Nutrigenomics: How Science Works

By Carsten Carlberg and Ferdinand Molnar

Book Overview

1 Nutrition and common diseases 1.1 Evolution of human nutrition 1.2 Principles of metabolism 1.3 Dietary molecules 1.4 Nutrition and metabolic diseases 1.5 Nutrition and cancer 1.6 Impact of physical activity2 Human genomic variation 2.1 Migration and evolutionary challenges of Homo sapiens 2.2 Diversity of human populations 2.3 Genetic variants of the human genome 2.4 Haplotype blocks and GWAS 2.5 The 1000 Genomes Project3 Sensing nutrition 3.1 Nutrient-sensing mechanisms 3.2 Nuclear receptors as nutrient sensors 3.3 Functions and actions of PPARs 3.4 Integration of lipid metabolism by LXRs and FXR 3.5 Coordination of the immune response by VDR 3.6 Circadian control of metabolic processes4 Interference of the human genome with nutrients 4.1 Human genetic adaptions 4.2 Genetic adaption to dietary changes 4.3 Regulatory SNPs and quantitative traits 4.4 Nutrigenomic analysis 4.5 Personal omics profiles5 Nutritional epigenetics 5.1 Epigenetic mechanisms 5.2 Intermediary metabolism and epigenetic signaling 5.3 Nutrition-triggered transgenerational epigenetic inheritance 5.4 Population epigenetics6 Nutritional signaling and aging 6.1 Aging and conserved nutrient-sensing pathways 6.2 Neuroendocrine regulation of aging 6.3 Principles of insulin signaling 6.4 Central role of FOXO transcription factors 6.5 Caloric restriction from yeast to mammals 6.6 Cellular energy status sensing by sirtuins and AMPK7 Chronic inflammation and metabolic stress 7.1 Central role of monocytes and macrophages 7.2 Acute and chronic inflammation 7.3 Reverse cholesterol transport and inflammation 7.4 Sensing metabolic stress via the ER8 Obesity 8.1 Definition of obesity 8.2 Adipogenesis 8.3 Inflammation in adipose tissue 8.4 Energy homeostasis and hormonal regulation of food uptake 8.5 Genetics of obesity9 Insulin resistance and diabetes 9.1 Glucose homeostasis 9.2 Insulin resistance in skeletal muscle and liver
9.3 β cell failure 9.4 Definition of diabetes 9.5 Disturbed glucose homeostasis in T2D and its treatment 9.6 Genetics and epigenetics of T2D10 Heart disease and the metabolic syndrome 10.1 Hypertension 10.2 Mechanisms of atherosclerosis 10.3 Lipoproteins and dyslipidemias 10.4 Whole body's perspective of the metabolic syndrome 10.5 Metabolic syndrome in key metabolic organs 10.6 Genetics and epigenetics of the metabolic syndrome

• Format: Paperback
• Language: English
• ISBN: 3030476634
• ISBN13: 9783030476632
• Release Date: May 2020
• Publisher: Springer
• Length: 181 Pages
• Weight: 0.64 lbs.
• Dimensions: 0.4" x 6.1" x 9.3"