This reprint presents a focused selection of contemporary research examining the current challenges and innovations in palliative and end-of-life care. The collected articles address the early identification of palliative needs, primary care and nursing roles, caregiver experiences, volunteer involvement, education, and public awareness, with contributions spanning qualitative, quantitative, mixed methods, and review studies. Drawing on evidence from diverse contexts around the world, this reprint highlights practical implementation issues and emerging strategies for improving access to high-quality and patient-centered palliative care, providing a valuable resource for clinicians, researchers, educators, and policymakers.