Multicomponent synthesis of 4H-pyran-3-carboxylate derivatives

By Dhaval B. Patel

A simple, versatile, one-pot, multi-component reaction (MCR) of ethyl 6-amino-5-cyano-2-methyl-4H-pyran-3-carboxylate derivatives has been achieved in the presence of urea as a potent catalyst in water-ethanol as a green solvent system. Reaction was proceeding via three component reaction by utilizing various aldehyde, malononitrile and ethylacetoacetate at room temperature. All Synthesized products were confirmed by Mass, 1H-NMR, IR and Melting point. Mild reaction conditions, excellent yields, easy isolation of products, no column chromatographic separation, reusability of reaction media.

• Format: Paperback
• Language: English
• ISBN: 6206151514
• ISBN13: 9786206151517
• Release Date: March 2023
• Publisher: LAP Lambert Academic Publishing
• Length: 56 Pages
• Weight: 0.21 lbs.
• Dimensions: 0.1" x 6.0" x 9.0"