Molecular Toxicology

By David Josephy, Bengt Mannervik, P. David Josephy

Molecular Toxicology reflects the revolution that toxicology has undergone in the last decade, as the molecular and genetic basis of the science--including drug metabolism, carcinogenesis, programmed cell death, and DNA repair--has been elucidated. It is the first text to explain the principles of toxicology in depth and from the perspective of modern biochemistry and molecular biology, while also providing a sense of the historical development of the science. Emphasizing the latest molecular biological approaches, the book covers xenobiotic biotransformation; reactive intermediates and their interactions with macromolecules; cloning, expression, and analysis of the enzymes of biotransformation; and molecular toxicology of aromatic amines, nitrosamines, polycyclic aromatic hydrocarbons, and chlorinated compounds. The toxicology of oxygen and oxidative stress is also covered in depth.
Extensively referenced, up-to-date, and rigorous, Molecular Toxicology is an ideal textbook for advanced undergraduate and graduate courses in molecular and biochemical toxicology, and also serves as a valuable resource for instructors and practicing scientists.

• Format: Hardcover
• Language: English
• ISBN: 0195093402
• ISBN13: 9780195093407
• Release Date: January 1997
• Publisher: Oxford University Press
• Length: 384 Pages
• Weight: 2.25 lbs.
• Dimensions: 10.3" x 1.1" x 7.3"