Mitochondrial Disorders: Biochemical and Molecular Analysis

Book Overview

Part I: Mitochondrial Disorder: A Complex Disease of the Two Genomes

1. Mitochondrial DNA Mutations: An Overview of Clinical and Molecular Aspects

William J. Craigen

2. Nuclear Gene Defects in Mitochondrial Disorders

Fernando Scaglia

19. Sequence Analysis of the Whole Mitochondrial Genome and Nuclear Genes Causing Mitochondrial Disorders

3. Diagnostic Challenges of Mitochondrial Disorders: Complexities of Two Genomes

Brett H. Graham

Part II: Biochemical Analysis of Mitochondrial Disorders

4. Biochemical Analyses of the Electron Transport Chain Complexes by Spectrophotometry

19. Sequence Analysis of the Whole Mitochondrial Genome and Nuclear Genes Causing Mitochondrial Disorders

Ann E. Frazier and David R. Thorburn

5. Measurement of Mitochondrial Oxygen Consumption Using A Clark Electrode

Zhihong Li and Brett H. Graham

6. Mitochondrial Respiratory Chain: Biochemical Analysis and Criterion for Deficiency in Diagnosis

19. Sequence Analysis of the Whole Mitochondrial Genome and Nuclear Genes Causing Mitochondrial Disorders

Manuela M. Grazina

7. Assays of Pyruvate Dehydrogenase Complex and Pyruvate Carboxylase Activity

19. Sequence Analysis of the Whole Mitochondrial Genome and Nuclear Genes Causing Mitochondrial Disorders

Douglas Kerr, George Grahame, and Ghunwa Nakouzi

8. Assessment of Thymidine Phosphorylase Function: Measurement of Plasma Thymidine (and Deoxyuridine) and Thymidine Phosphosphorylase Activity

19. Sequence Analysis of the Whole Mitochondrial Genome and Nuclear Genes Causing Mitochondrial Disorders

Ramon Mart?, Luis C. L?pez, and Michio Hirano

9. Measurement of Mitochondrial dNTP Pools

19. Sequence Analysis of the Whole Mitochondrial Genome and Nuclear Genes Causing Mitochondrial Disorders

Ramon Mart?, Beatriz Dorado, and Michio Hirano

10. Measurement of Oxidized and Reduced Coenzyme Q in Biological Fluids, Cells, and Tissues: An HPLC-EC Method

19. Sequence Analysis of the Whole Mitochondrial Genome and Nuclear Genes Causing Mitochondrial Disorders

Peter H. Tang and Michael V. Miles

11. Assay to Measure Oxidized and Reduced Forms of CoQ by LC-MS/MS

19. Sequence Analysis of the Whole Mitochondrial Genome and Nuclear Genes Causing Mitochondrial Disorders

Si Houn Hahn, Sandra Kerfoot, and Valeria Vasta

12. Morphological Assessment of Mitochondrial Respiratory Chain Function on Tissue Sections

19. Sequence Analysis of the Whole Mitochondrial Genome and Nuclear Genes Causing Mitochondrial Disorders

Kurenai Tanji

13. Blue Native Polyacrylamide Gel Electrophoresis: A Powerful Diagnostic Tool for the Detection of Assembly Defects in the Enzyme Complexes of Oxidative Phosphorylation

19. Sequence Analysis of the Whole Mitochondrial Genome and Nuclear Genes Causing Mitochondrial Disorders

Scot C. Leary

14. Radioactive Labeling of Mitochondrial Translation Products in Cultured Cells

19. Sequence Analysis of the Whole Mitochondrial Genome and Nuclear Genes Causing Mitochondrial Disorders

Florin Sasarman and Eric A. Shoubridge

15. Transmitochondrial Cybrids:

• Format: Paperback
• Language: English
• ISBN: 1493959506
• ISBN13: 9781493959501
• Release Date: August 2016
• Publisher: Humana
• Length: 353 Pages
• Weight: 1.40 lbs.
• Dimensions: 0.8" x 7.0" x 10.0"