Section I.- General principles of mitochondria and the heart 1.- Introduction to mitochondria in the heart 2.-Methods to study mitochondrial structure and function 3.- Mitochondrial structure, composition and dynamics 4.- Mitochondrial biogenesis 5.- Mechanisms of bioenergy production in mitochondria 6.- Bioenergetics interplay between cardiac mitochondria and other subcellular compartments Section II.- Heart mitochondria signal transduction: Stem cells 7) Endothelial mitochondria: Contribution to cardiovascular function and disease 8.- Heart mitochondria: Receivers and transmitters of signals 9.- Stem cells and mitochondria Section III.- Stress and cell death 10.- Heart mitochondrial ROS and oxidative stress 11.- Cell death pathways and mitochondria Section IV.- Mitochondria in pediatric cardiology 12.- Mitochondria in pediatric cardiovascular diseases Section V.- The aging heart and mitochondria 13.- Mitochondrial in the aging heart Section VI.- Mitochondria in atherosclerosis, hypertension and ischemia 14.- The role of mitochondria in atherosclerosis 15.- The role of mitochondria in hypertension 16.- Role of mitochondria in ischemia and cardioprotection Section VII.- Mitochondria in heart failure and dysrhythmias 17.- Mitochondrial dynamics in health and disease 18.- Mitochondria play an essential role in heart failure 19.- Mitochondria and cardiac dysrhythmias Section VIII.- Mitochondria in heart metabolism 20.- Diabetes and cardiac mitochondria 21.- The role of mitochondria in metabolic syndrome and insulin resistance 22.-Thyroid hormone and myocardial mitochondria Section IX.- Mitochondrial therapy 23.- Targeting the mitochondria in cardiovascular diseases Section X.- Looking to the future of mitochondria and the heart 24.- Current progress and future perspectives: Towards mitochondrial medicine