Before mifepristone was approved for medical use, it underwent extensive preclinical testing that included in vitro and in vivo studies. In vitro studies were conducted to investigate the pharmacological activity of mifepristone and analyze various aspects of its pharmacokinetics and pharmacodynamics. In vivo studies were conducted to assess its efficacy, safety, and tolerability in animals. The preclinical trials showed that mifepristone was able to block the progesterone receptor in animals, thus preventing the uterus from accepting a fertilized egg. It was also found to be quickly absorbed after oral administration and had minimal side effects, making it an attractive option for early use in humans.
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