Metodologiya lokus-spetsificheskogo analiza metilirovaniya DNK: Genomnyy podkhod

By Vladimir Strel'nikov

Metilirovanie raspredeleno na protyazhenii CpG-ostrovkov genoma cheloveka neravnomerno i modifikatsiya razlichnykh CpG-dinukleotidov po-raznomu vliyaet na ekspressiyu genov. Pravil'nyy dizayn laboratornykh protokolov dlya opredeleniya metilirovaniya DNK mozhet osnovyvat'sya tol'ko na dostovernoy informatsii o strukturno-funktsional'noy organizatsii izuchaemykh C, G-bogatykh oblastey. Na segodnyashniy den' podobnaya informatsiya otsutstvuet dlya bol'shinstva, dazhe naibolee khorosho izuchennykh, genov, vovlechyennykh v kantserogenez. V svyazi s etim osoboe znachenie priobretaet podrobnaya individual'naya kharakteristika osobennostey genomnykh lokusov, differentsial'noe metilirovanie kotorykh assotsiirovano s razvitiem zlokachestvennykh novoobrazovaniy. V monografii opisany sovremennye podkhody k vyboru genomnykh lokusov dlya analiza differentsial'nogo metilirovaniya DNK i trebovaniya k dizaynu test-sistem, prednaznachennykh dlya lokus-spetsificheskogo analiza

• Format: Paperback
• Language: Russian
• ISBN: 3659670413
• ISBN13: 9783659670411
• Release Date: December 2014
• Publisher: LAP Lambert Academic Publishing
• Length: 104 Pages
• Weight: 0.36 lbs.
• Dimensions: 0.3" x 6.0" x 9.0"