Methods for Reversing Protein Modification: Ubiquitin and Sumo-Specific Proteases

By Tasneem Bawa-Khalfe and Jinke Cheng

Protein posttranslational modification with peptide tags ubiquitin or small ubiquitin-like modifier (SUMO) orchestrate multiple cellular events to ensure normal physiology. These simple enzymatic activities maintain homeostasis of protein modification and normal cell function. This book addresses major proteases - ubiquitin and/or SUMO proteases - involved in posttranslational modification of proteins. Themes reviewed include the difficulty of assigning substrate specificity to the individual de-ubiquitylases (DUBs), selectivity for processing ubiquitin poly-chains, and defining substrate profiles for the different SUMO proteases.

Key selling features:

Assigns substrate specificity to enzymes that constitute the de-ubiquitylase (DUB) family Describes DUBs selectivity for processing select ubiquitin poly-chains Defines substrate profiles for the different small ubiquitin-like modifier (SUMO) proteases Explores enzymatic activity of individual Ubiquitin/SUMO proteases

• Format: Hardcover
• Language: English
• ISBN: 1138196541
• ISBN13: 9781138196544
• Release Date: January 2021
• Publisher: CRC Press
• Length: 300 Pages