Lyme disease occurs much more frequently in dogs than in cats. When infected, cats may show lameness, fever, loss of appetite, fatigue, or difficulty breathing. Lyme disease can also affect the kidneys, joints, nervous system, and heart. Many cats do not show noticeable signs, despite being infected.
The diagnosis of Lyme disease is based on history, signs of disease, laboratory tests, and elimination of other disorders. Additional tests may be necessary depending on which part of the body is affected. Antibiotics are required for treatment in all animals that display signs of Lyme disease. Rapid response is seen in limb and joint disease in most cases, although the signs do not completely resolve in a significant number of affected animals. The infection may persist in spite of antibiotic treatment, and a second round of treatment may be necessary. Additional therapy to help the affected organ systems and signs is also important, especially when the disease affects the kidneys, heart, or nerves.