Leptin: Regulation and Clinical Applications

Book Overview

Discovery of leptin and elucidation of leptin gene expression.- Leptin receptors and mechanism of action.- Leptin interaction with brain orexigenic and anorexigenic pathways.- Measurement of circulating leptin and soluble leptin receptors.- Physiological and hormonal factors that influence leptin production.- Leptin, obesity and leptin resistance.- Leptin and intermediary metabolism: Focus on glucoregulation and lipid metabolism.- Leptin in acute stress.- Leptin and the kidney.- Leptin, immune function, and inflammation.- Leptin and bone.- Leptin, cell cycle, and cancer.- Leptin, the autonomic nervous system, and hypertension.- Dynamic leptin secretion in obesity and diabetes.- Leptin therapy of congenital leptin deficiency.- Leptin therapy in people with normal leptin gene.- Leptin therapy in patients with lipodystrophy and syndromic insulin resistance.- Leptin therapy in women with hypothalamic amenorrhea.- Leptin therapy as a substitute for insulin replacement in experimental models of diabetes: Clinical implications in humans.- Novel combinatorial therapies involving leptin: Opportunities for mechanistic advances and therapeutic translation in human diseases.

• Format: Paperback
• Language: English
• ISBN: 3319354132
• ISBN13: 9783319354132
• Release Date: August 2016
• Publisher: Springer
• Length: 287 Pages
• Weight: 1.20 lbs.
• Dimensions: 0.7" x 7.0" x 10.0"