Itch: Mechanisms and Treatment

Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain.

Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer.

Composed of contributions from distinguished researchers around the world, the book explores topics such as:

Neuropathic itch

Peripheral neuronal mechanism of itch

The role of PAR-2 in neuroimmune communication and itch

Mrgprs as itch receptors

The role of interleukin-31 and oncostatin M in itch and neuroimmune communication

Spinal coding of itch and pain

Spinal microcircuits and the regulation of itch

Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

• Format: Hardcover
• Language: English
• ISBN: 1466505435
• ISBN13: 9781466505438
• Release Date: February 2014
• Publisher: CRC Press
• Length: 494 Pages
• Weight: 1.10 lbs.
• Dimensions: 0.8" x 6.2" x 9.3"