Immunological investigation of autoimmune bullous dermatoses

By Ameni Jerbi

Autoimmune bullous dermatoses (ABD) are specific autoimmune diseases of the skin and mucous membranes. They are characterized by the presence of autoantibodies (auto-Ab) directed against skin and mucous membrane adhesion molecules, leading to altered function of their antigenic targets, resulting in clinical bullae and/or erosions. Depending on the site of cleavage, a distinction is made between intra-epidermal DBAI, characterized by auto-Ac directed against the structural proteins of the desmosomes that hold the keratinocytes of the epidermis together; and sub-epidermal DBAI, characterized by the presence of auto-Ac directed against the components of the dermo-epidermal junction (DEJ).The diagnosis of DBAI is based on clinical, histopathological and immunological evidence (detection of circulating or tissue-deposited auto-Ac). Direct immunofluorescence (DIF) is an immunological technique performed on cryosections of peri-lesional biopsies, based on the detection of Ac deposits and/or complement fractions using specific fluorescein-conjugated Ac.

• Format: Paperback
• Language: English
• ISBN: 6208187877
• ISBN13: 9786208187873
• Release Date: October 2024
• Publisher: Our Knowledge Publishing
• Length: 52 Pages
• Weight: 0.20 lbs.
• Dimensions: 0.1" x 6.0" x 9.0"