This document is intended to assist immunization program managers and national regulatory authorities in establishing and/or strengthening immunization safety surveillance systems. The first edition of the Regional Immunization Safety Surveillance: Guidelines for Managers of Immunization Programmes on Reporting and Investigating Adverse Events Following Immunization was published in 1999. Over the following decade, significant developments were made in the field of immunization safety, in both knowledge and practices. In 2012, the Expanded Programme on Immunization (EPI), at the WHO Regional Office for the Western Pacific, undertook an extensive revision of the guidelines, which resulted in the Second Edition. This Third Edition, in 2015, covers the most up-to-date information available in vaccine and immunization safety globally.
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