Immune Alterations in Male and Female Mice After 2-Deoxy-D-Glucose Administration

By National Aeronautics and Space Administration

Administration of 2-deoxy-D-glucose (2-DG), an analog of glucose which inhibits glycolysis by competitive antagonism for phosphohexose isomerase, results in acute periods of intracellular glucoprivation and hyperglycemia resulting in hyperphagia. In addition to these changes in the carbohydrate metabolism, injection of 2-DG results in alterations of both the endocrine and neurological systems as suggested by modifications in oxytocin and glucocorticoid levels and norepinephrine production. Moreover, alterations of the immune response, such as a decrease in the in vitro proliferation of splenocytes after mitogen-stimulation, were observed in mice injected with 2-DG. Sex, genotype and environment are among the factors that may modulate effects of catecholamines and hypothalamo-pituitary-adrenal axis on these immune changes. Sexual dimorphism in immune function resulting from the effects of sex hormones on immune effector cells has been shown in both animals and humans. These observations have important implications, especially with regard to higher incidence of many autoimmune diseases in females. Evidence exists that reproductive hormones influence the immune system and increase the risk of immunologically related disorders in both animals and humans. Indeed, immunological responses in stressful situations may also be confounded by fluctuations of sex hormones especially in females. Lymphocyte distribution, cytoldne production, and the ability of lymphocyte to proliferate in vitro were analyzed in male and female mice to determine if sex influenced 2-DG immunomodulation. In addition, the influence of hormones, especially sex hormones, on these changes were evaluated. Dreau, Didier and Morton, Darla S. and Foster, Mareva and Swiggett, Jeanene P. and Sonnenfeld, Gerald Ames Research Center NAG2-933; NAG9-728...

• Format: Paperback
• Language: English
• ISBN: 1729025528
• ISBN13: 9781729025529
• Release Date: January 1
• Publisher: Independently Published
• Length: 30 Pages
• Weight: 0.21 lbs.
• Dimensions: 0.1" x 8.5" x 11.0"