Il-17, Il-22 and Their Producing Cells: Role in Inflammation and Autoimmunity

Book Overview

IL-17A family, receptors, proinflammatory effects and production.- IL-22 and IL-17 overview.- IL-17R family: Structure, signal transduction and function.- Contribution of IL-22 to Th17 responses: repairing and protecting peripheral tissues.- Central role of Th-17 cells in adaptive immune responses.- Regulatory T cells vs Th17: Differentiation of Th17 versus Treg are they mutually exclusive Other sources of IL-17: iNKT cells.- Retinoic acid in mucosal immune regulation.- Critical role of IL-17 in experimental arthritis.- Dual role IL-17A, F and IL-22 in allergic asthma.- Inflammasome - IL-1 - IL-17 response in lung inflammation.- The role of Il-17 in exp autoimmune mycocarditis.- Th17 cells in transplantation: actors or innocent bystanders.- Is IL-17 required to control of tuberculosis IL-17 and mucosal host defense. Role of IL-17 and IL-17 family cytokines on tumor development.- IL-17 and TH17 cells in rheumatoid arthritis and other inflammatory conditions.- Targeting Th17 Cells for therapy of multiple sclerosis.- Involvement of interleukin-17 cytokines in human asthma.- IL-17 and/or IL-22 as potential target(s) for Crohn's disease.- Role of IL-23, IL-17 and IL-22 in psoriasis.- Contribution of IL-22 to experimental skin inflammation.- Genetic mouse models to investigate IL-17 responses.- IL-17A as a therapeutic target for autoimmune diseases.

• Format: Hardcover
• Language: English
• ISBN: 3034805217
• ISBN13: 9783034805216
• Release Date: December 2012
• Publisher: Springer
• Length: 354 Pages
• Weight: 1.45 lbs.
• Dimensions: 0.9" x 6.4" x 9.5"