I Domains in Integrins

By Donald Gullberg

In vertebrates, the integrin family includes 24 members. As the alpha-chains were sequenced, some were observed to have an inserted domain similar to the A domain in several matrix and complement proteins. This inserted ligand binding domain is interactive and was called the I domain in integrins. More recently structural data have shown that an integrin beta-chain also contains an I domain. Nine of the currently known 18 alpha-chains contain an I domain. This book systematically goes through the current knowledge about these integrins, including the newest additions to the integrin family, the collagen-binding alpha10beta1 and alpha11beta1 integrins. The book discusses ligand binding, signalling properties, knock-out phenotypes and possible involvement in disease. This book comprehensively reviews the current knowledge about I domains in integrins and will serve as a useful reference book for scientists in this field.

• Format: Hardcover
• Language: English
• ISBN: 0306478366
• ISBN13: 9780306478369
• Release Date: July 2003
• Publisher: Springer
• Length: 186 Pages
• Weight: 1.13 lbs.
• Dimensions: 0.8" x 6.2" x 9.5"