Histone Recognition

Book Overview

The Bromodomain as the Acetyl-Lysine Binding Domain in Gene Transcription.- PHD Fingers as Histone Readers.- Methyl-Lysine Recognition by the Royal Family Modules: Chromo, Tudor, MBT, Chromo Barrel, and PWWP Domains.- Histone Recognition by WD40 Proteins.- Methyl-Lys Recognition by Ankyrin Repeat Proteins.- Methyl-Arginine Recognition by Tudor Domains.- Histone Recognition by Tandem Modules and Modulation by Multiple PTMs.- Genome-Wide Profiling of Molecular Recognition of Histone PTMs.- BET Bromodomain Inhibition as a Therapeutic Approach in Hematological Malignancies.- Anti-Inflammatory Effects of BET Protein Inhibition Through Modulation of Gene Transcription.- Activating Latent HIV by Inhibiting Bromodomain Proteins.- Small Molecule Modulation of Methyl-Lysine Mediated Interactions.

• Format: Paperback
• Language: English
• ISBN: 3319376667
• ISBN13: 9783319376660
• Release Date: October 2016
• Publisher: Springer
• Length: 282 Pages
• Weight: 0.91 lbs.
• Dimensions: 0.6" x 6.1" x 9.2"