Histamine Receptors: Preclinical and Clinical Aspects

Book Overview

Molecular aspects of histamine receptors.- Genetic polymorphisms in the histamine receptor family.- The role of the histamine H4 receptor in asthma and atopic dermatitis.- Identification and roles of zebrafish histamine receptors.- Histamine H3r antagonists: from scaffold hopping to clinical candidates.- Clinical significance of histamine H1 receptor gene expression and drug action of antihistamines.- Histamine and its receptors as a module of the biogenic amine diseasome.- Histaminergic regulation of blood-brain barrier activity.- Histamine function in nervous systems.- Heterogeneity of histaminergic neurons.- Modulation by histamine H3 receptors of neurotransmitter release in the basal ganglia.- Interaction of brain histaminergic and dopaminergic systems.- Histamine H1 Receptor Occupancy in Human Brain Measured by Positron Emission Tomography.- Modulation of memory consolidation and extinction by brain histamine.- Histamine and appetite.

• Format: Paperback
• Language: English
• ISBN: 3319820745
• ISBN13: 9783319820743
• Release Date: June 2018
• Publisher: Humana
• Length: 373 Pages
• Weight: 1.19 lbs.
• Dimensions: 0.8" x 6.1" x 9.2"