from a disequilibrium of gathered histamine and the ability for histamine degradation. The essential enzyme for metabolism of ingested histamine is diamine oxidase (DAO) (1-5). An impaired histamine degradation based totally on a decreased DAO exercise and the ensuing extra of histamine may additionally reason severa signs and symptoms mimicking an allergic reaction. Ingestion of histamine-rich meals (6), alcohol (7-9), or capsules (10-13) that launch histamine or block DAO may additionally provoke diarrhea, headache (14), congestion of the nose, asthmatoid wheezing (6, 8, 15), hypotension, arrhythmia, urticaria (16, 17), pruritus, flushing, and different prerequisites in these patients. Approximately 1% of the populace has histamine intolerance, and 80% of these sufferers are middle-aged (18). Because of the multifaceted symptoms, the existence of histamine intolerance is regularly underestimated, or its signs are misinterpreted.
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