Part I. Chronic Hepatitis C.- 1. Natural History of chronic hepatitis C (Jake Liang and Marc Ghany).- 2. The Multifaceted Features of HCV Infection beyond the Liver (Kazuhiko Koike).- 3. Hepatic Fibrosis in Hepatitis C (Melissa A. Sheiko and Hugo R. Rosen).- 4. Hepatocellular Carcinoma and Hepatitis C Virus (Sheng-Han Wang, Shiou-Hwei Yeh, and Pei-Jer Chen).- 5. HCV, Alcohol, and the Liver (Terence N. Bukong, Banishree Saha, and Gyongyi Szabo).- 6. Extrahepatic Replication of HCV (Wen-Chi Su, Keigo Machida, and Michael M.C. Lai).- Part II. HCV Infections in Special Populations.- 7. Hepatitis C virus infection in pregnancy and children (Jessica Wen, Samantha Ohmer, Jonathan Honegger).- Part III. Approaches to Therapy.- 8. Host Genetics and Responses to Antiviral Therapy in Chronic Hepatitis C (Yasuhito Tanaka and Masashi Mizokami).- 9. Viral Variation and Response to Therapy (Shinya Maekawa and Nobuyuki Enomoto).- 10. HCV NS3/4A Protease Inhibitors and the Road to Effective Direct-acting Antiviral Therapies (Nicolas Tremblay, Alex Young Park, and Daniel Lamarre).- 11. Modeling HCV Dynamics in Clinical Practice to Personalize Antiviral Therapy (Piero Colombatto, Ferruccio Bonino, Luigi Civitano, Filippo Oliveri, Gabriele Ricco, Sergio Iannazzo, and Maurizia R. Brunetto).- Part IV. Prevention and Control of HCV Infection.- 12. Prophylactic Vaccines for the Hepatitis C Virus (Andrea L. Cox).- 13. Global control of hepatitis C infection (Tatsuo Miyamura).
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