Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics

By A. Gerson Greenburg and Hae Won Kim

Book Overview

Brief historical account of HBOC development.- Physiology of respiration.- Oxygen transport to tissues.- Pathophysiology of acute anemia.- Global blood safety and need for safe blood supply.- Blood transfusion and its limitations.- Scientific basis and design of HBOCs.- HBOCs: a regulatory perspective.- Current HBOC products in development.- Clinical indications and clinical trials of HBOCs.- HBOCs and adverse events observed in clinical trials.- HBOC-mediated vasoactivity and hypertension.- HBOC and oxygen and nitrogen radical mediated toxicity.- HBOCs and clinical laboratory interference.- Animal models for HBOC studies.- New emerging Technologies for universal RBCs.- Future prospects.

• Format: Paperback
• Language: English
• ISBN: 3662508079
• ISBN13: 9783662508077
• Release Date: September 2016
• Publisher: Springer
• Length: 746 Pages
• Weight: 2.34 lbs.
• Dimensions: 1.5" x 6.1" x 9.2"