Growth Hormone Secretagogues in Clinical Practice

By Richard F Walker, Barry B. Bercu, Richard F. Walker

Book Overview

0-8247-9832-5 Recognizing the urgent need for an up-to-date review of new and innovative research on growth hormone (GH) secretagogues, this exclusive work furnishes the state of the art on the mechanisms of action, design, synthesis, evaluation, and clinical applications of GH secretagogues, including orally active and xenobiotic GH-releasing compounds.
Beginning with a thorough historical perspective on the discovery and evolution of GH-releasing peptides (GHRPs) as therapeutic agents, Growth Hormone Secretagogues in Clinical Practice
analyzes structural requirements for GH secretagogue efficacy
demonstrates the use of mathematical models to predict differential values of individual stimuli for GH secretion from the pituitary
reports on the development of a simple screening system based on polyclonal antibodies
discusses laboratory synthesis of agonistic analogs intended for human and veterinary use
proposes applications in managing conditions such as Turner's syndrome, acromegaly, diabetic retinopathy, glomerulosclerosis, tumors, and cancer
provides physiological evidence for the effects of GHRP on behavior with a series of trials involving voluntary and forced exercise
describes a new diagnostic test for evaluating pituitary function in slowly growing children and aging adults
explores the interactions of GH secretagogues with other hormones and endogenous substances from sex steroids to interferons
and much more
Scope of Non-GHRH Growth Hormone Secretagogues

Synergistic Release of Growth Hormone by GHRP and GHRH: Scope and Implication, Cyril Y. Bowers
Structural Requirements of Growth Hormone Secretagogues, Romano Deghenghi
Unifying Mechanism of a Non-GHRH Growth Hormone Secretagogue's Action, Roy G. Smith
Molecular Cloning and Characterization of Human, Swine, and Rat Growth Hormone Secretagogue Receptors, Lex H. T. Van der Pl

• Format: Paperback
• Language: English
• ISBN: 0367400480
• ISBN13: 9780367400484
• Release Date: September 2019
• Publisher: CRC Press
• Length: 464 Pages
• Weight: 1.36 lbs.
• Dimensions: 0.9" x 6.0" x 9.0"