Gestational Trophoblastic Disease: Diagnostic and Molecular Genetic Pathology
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Preface and Dedication
Chapter 1: Gestational Trophoblastic Disease: General Aspects (Pei Hui)
- Historical remarks
- Definition and classification of gestational trophoblastic disease
- Epidemiology and risk factors
- Overview of diagnosis
- Overview of clinical management
- Perspectives
- References
Chapter 2: Developmental Biology of the Placenta (Pei Hui)
- Introduction
- Placenta formation
- Stages of implantation
- Placental trophoblastic cells
- Genomic imprinting and placental development
- Imprinted X chromosomal inactivation and placental development
- Co-evolution of genomic imprinting and imprinted X-chromosome inactivation
- "Parental conflict of interest" theory of genomic imprinting
- References
Chapter 3: Genetic Basis of Gestational Trophoblastic Disease (Pei Hui)
- Introduction
- Androgenetic nature of hydatidiform moles
- Genomic imprinting and hydatidiform moles
- Genetic basis of gestational trophoblastic tumors
- Perspectives
- References
Chapter 4: Complete hydatidiform mole (Pei Hui)
- Introduction
- Pathogenesis
- Clinical presentation
- Pathology
- Ancillary studies
- Differential diagnosis
- Clinicopathological correlations
- References
Chapter 5: Partial hydatidiform mole (Natalia Buza)
- Introduction
- Genetic background
- Clinical presentation
- Pathology gross and microscopic features
- Ancillary studies
- Differential diagnosis
- Clinicopathological correlations
- References
Chapter 6: Placental site trophoblastic tumor (PSTT) (Pei Hui)
- Introduction
- Clinical presentation
- Pathogenesis
- Gross and histological pathology
- Ancillary studies
- Differential diagnosis
- Clinicopathological correlations
- References
Chapter 7: Epithelioid trophoblastic tumor (Katja Gwinn)
- Introduction
- Pathogenesis and molecular genetic aspect
- Clinical presentation
- Pathology
- Ancillary studies
- Differential diagnosis
- Clinicopathological correlations
- References
Chapter 8: Gestational choriocarcinoma (Pei Hui)
- Introduction
- Clinical presentation
- Pathogenesis
- Pathology
- Ancillary studies
- Differential diagnosis
- Clinicopathological correlations
- References
Chapter 9: Persistent gestational trophoblastic neoplasia (Pei Hui)
- Introduction
- Pathology
o Persistent mole
o Invasive mole and metastatic mole
o Gestational trophoblastic tumors
- Prognosis
- References
Chapter 10: Tumor-like trophoblastic conditions (Pei Hui)
- Introduction
- Placental site nodule/plaque (PSN)
o Clinical features
o Pathogenesis
o Pathology
o Ancillary studies
o Differential diagnosis
o Clinicopathological correlations
- Exaggerated placental site reaction (EPS)
o Clinical features
o Pathogenesis
o Pathology
o Ancillary studies
o Differential diagnosis
o Clinicopathological correlations
- Refer
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