Gene Delivery by Protein-Polymer Nanoconjugates

By Heidar-Ali Tajmir-Riahi

In this book, we explore the potential applications of protein-polymer nanoconjugates in gene delivery. Conjugation of human serum albumin (HSA), bovine serum albumin (BSA) and beta-lactoglobulin (β-LG) with chitosan (carbohydrates) and PAMAM (dendrimers) of different sizes were used to transport DNA and RNA. Thermodynamic analysis showed that the conjugation of DNA and RNA to protein-polymer nanoparticles occurred via hydrophilic, hydrophobic, H-bonding and van der Waals contacts. As the size of portion-polymer nanoconjugate increased, the loading efficacy of DNA and RNA was increased (40% to 60%). Major alterations of DNA and RNA morphology occurred by nanoparticle interaction. Protein-polymer nanoconjugates are capable of delivering DNA and RNA to the target molecules.

• Format: Paperback
• Language: English
• ISBN: 6200232229
• ISBN13: 9786200232229
• Release Date: September 2019
• Publisher: LAP Lambert Academic Publishing
• Length: 72 Pages
• Weight: 0.26 lbs.
• Dimensions: 0.2" x 6.0" x 9.0"