Gabab Receptor

Book Overview

1. Historical Perspectives on the GABAB Receptor.- Section 1. Chemistry.- 2. Chemistry of GABAB Receptor Ligands: Focus on Agonists and Antagonists.- 3. Chemistry of GABAB Receptor Ligands: Focus on Positive Allosteric Modulators.- Section 2. Molecular Biology, Biochemistry, & Physiology.- 4. Molecular Structure and Trafficking of the GABAB Receptor.- 5. Distribution and Localization of the GABAB Receptor.- 6. Activation Mechanism and Allosteric Properties of the GABAB Receptor.- 7. Modulation of Neurotransmission by the GABAB Receptor.- 8. GABAB Receptor Functions In The Mesolimbic Dopamine System.- Section 3. Pharmacology.- 9. Drug Discrimination Studies for Investigations on the Mechanisms of Action of GABAB Receptor Ligands.- 10. Targeting the GABAB Receptor for the Treatment of Epilepsy.- 11. Targeting the GABAB Receptor for the Treatment of Pain.- 12. Targeting the GABAB Receptor for the Treatment of Psychiatric Disorders.- 13. Targeting the GABAB Receptor for the Treatment of Fragile X Syndrome and Autism Spectrum Disorders.- 14. Targeting the GABAB Receptor for the Treatment of Substance Use Disorder.- 15. Targeting the GABAB Receptor for the Treatment of Alcohol Use Disorder.- 16. Targeting GABAB Receptors for the Treatment of Gastroesophageal Reflux Disease and Chronic Cough.- 17. Baclofen: Therapeutic Use and Potential of the Prototypic GABAB Receptor Agonist.- 18. Allosteric Modulators: The New Generation of GABAB Receptor Ligands.- 19. GABAB Receptor Antagonists as Cognition Enhancers.

• Format: Paperback
• Language: English
• ISBN: 3319834282
• ISBN13: 9783319834283
• Release Date: June 2018
• Publisher: Humana
• Length: 385 Pages
• Weight: 1.25 lbs.
• Dimensions: 0.8" x 6.1" x 9.3"