Functional Selectivity of G Protein-Coupled Receptor Ligands: New Opportunities for Drug Discovery

Book Overview

Historical Overview of the Concept of Functional Selectivity.- Functional Selectivity: Theoretical Considerations and Future Directions.- Agonist Selective Coupling of G Protein-Coupled Receptors.- Ligand-Selective Receptor Desensitization and Endocytosis.- Selectivity for G protein or Arrestin-Mediated Signaling.- In Vivo Evidence for and Consequences of Functional Selectivity.- Functional Selectivity at Adrenergic Receptors.- Signaling Diversity Mediated by Muscarinic Acetylcholine Receptor Subtypes and Evidence for Functional Selectivity.- Functional Selectivity at Serotonin Receptors.- Functional Selectivity at Dopamine Receptors.- Functional Selectivity at Receptors for Cannabinoids and other Lipids.- Functional Selectivity at Opioid Receptors Graciela Pi?eyro.- Functional Selectivity at non-Opioid Peptide Receptors

• Format: Paperback
• Language: English
• ISBN: 1493961160
• ISBN13: 9781493961160
• Release Date: August 2016
• Publisher: Humana
• Length: 292 Pages
• Weight: 0.94 lbs.
• Dimensions: 0.6" x 6.1" x 9.2"