Chapter-1: Current Landscape in System Biology and Functional Proteomics. Chapter-2: Making the Case for Functional Proteomics Chapter-3: Technology Overview Chapter-4: Sample Collection and Processing (protocol) Chapter-5: Serum Protein Enrichment (protocol) Chapter-6: Gel-based Technologies (protocol) Chapter-7: PEP Platform (protocol) Chapter-8: Mass Spectrometry-based Technologies