Formulation and Evaluation of Mucoadhesive Drug Delivery Systems

Bys: Kulkarni, Gururaj S., A. S., Ankithasirinayana, Choudhary, Vikram T.

Buccal drug delivery bypasses hepatic first-pass metabolism, offering improved bioavailability over conventional oral administration. This work presents the formulation and evaluation of mucoadhesive buccal tablets of Salbutamol sulphate using natural polymers-Xanthan gum, Guar gum, and Sodium alginate.FTIR and DSC studies confirmed drug-excipient compatibility. Thirty formulations prepared by direct compression, with Ethyl cellulose as a backing layer, met all standard physicochemical parameters. In-vitro dissolution showed up to 100.81% drug release over 8 hours following zero-order kinetics. In-vivo studies on rabbits confirmed 87.37% buccal absorption with sustained plasma levels and higher AUC than oral administration. Good in-vitro/in-vivo correlation and three-month stability were demonstrated.These results establish mucoadhesive buccal tablets as an effective, stable, and bioavailable dosage form for asthma management.

• Format: Paperback
• Language: English
• ISBN: 620960692X
• ISBN13: 9786209606922
• Release Date: March 2026
• Publisher: LAP Lambert Academic Publishing
• Length: 124 Pages
• Weight: 0.39 lbs.
• Dimensions: 0.3" x 6.0" x 9.0"