Formulating Poorly Water Soluble Drugs

By Robert O. Williams III

Book Overview

The objective of this third edition is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist's approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound's physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at a minimum a working knowledge of each of the above mentioned facetsand detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop.

• Format: Hardcover
• Language: English
• ISBN: 3030887189
• ISBN13: 9783030887186
• Release Date: May 2022
• Publisher: Springer
• Length: 693 Pages
• Weight: 3.16 lbs.
• Dimensions: 1.5" x 7.0" x 10.0"