Fatal Cells and Fetal DNA in Maternal Blood: New Developments for a New Millenium : 11th Fetal Cell Workshop, Basel, April 15, 2000

By Wolfgang Holzgreve and Sinuhe Hahn

Is noninvasive, risk-free prenatal diagnosis of fetal genetic characteristics still a fantasy, or will it soon become reality? The current status of both the leading European research groups as well as the NIH-funded NIFTY study are reported here, indicating that certain fetal genetic traits can now be examined efficiently in a noninvasive manner. Considerable focus is placed on new laser-mediated systems for the effective micro-manipulation of single fetal cells, as well as their analysis by single-cell PCR and the pitfalls to avoid when performing such analyses. Other issues addressed in depth include: novel enrichment techniques, optimal fetal cell recognition, fetal cell culture, as well as the exciting finding that fetal cell traffic is elevated in certain pregnancy-related disorders, most prominently in preeclampsia. This publication is of interest to researchers in the field, genetic counsellors, gynecologists and obstetricians, and researchers in microchimerism, transplantation and transfusion medicine.

• Format: Hardcover
• Language: English
• ISBN: 3805572220
• ISBN13: 9783805572224
• Release Date: January 2001
• Publisher: S Karger Ag
• Length: 160 Pages
• Weight: 0.96 lbs.
• Dimensions: 9.5" x 0.5" x 6.8"