Eukaryotic Mrna Processing

The control of gene expression occurs at many levels, including transcription, RNA maturation, and translation. Eukaryotic messenger RNA's undergo a variety of complex processing reactions, each one essential for gene expression and its proper regulation. This volume focuses on the major mRNA maturation reactions, primarily those that take place in the nucleus of eukaryotic cells. Topics include: the assembly of newly synthesized nuclear mRNA transcripts into hnRNP particles and catalyically active spliceosomes; the structure and mechanism of action of small nuclear ribonucleoprotein particles and protein factors that catalyze pre-mRNA splicing in mammalian cells and in yeast; the regulation of gene expression and generation of protein isoform diversity by alternative splicing; the mechanisms of 3' end cleavage and polyadenylation; the architecture of the cell nucleus in relation to these processes and to the localization of the relevant substrates and factors; the diverse mechanisms of RNA processing by ribozymes and theior potential relevance for nuclear mRNA processing; the mechanisms of pliced-leader addition by trans-splicing in nematodes and tryanosomes; and the process of insertion/deletion mRNA editing in kinetoplasmid protozoa. Leading researchers provide detailed critical reviews of the history, experimental approaches, major advances, current models, and future directions for these areas of research. New students to mRNA in particular will find it useful and inspiring.

• Format: Paperback
• Language: English
• ISBN: 0199634173
• ISBN13: 9780199634170
• Release Date: November 1997
• Publisher: IRL Press
• Length: 396 Pages
• Weight: 1.60 lbs.
• Dimensions: 0.9" x 7.3" x 9.8"