This open access book is tailored to connect robotics and human factors in real-world contexts, offering essential guidance for designing and evaluating human-centered robotic systems through the approaches of ergonomics. Drawing on the latest advances in physical, cognitive, and organizational ergonomics, it provides a set of comprehensive frameworks on human-robot interaction. Organized in five thematic sections, the book moves from foundational concepts to applied domains, enabling technologies, groundbreaking developments, and societal aspects. Designed for researchers, students, and professionals whose expertise moves across (and beyond) disciplinary fields like engineering, psychology, computer science, medicine, and design, this book welcomes readers from any background seeking to improve human well-being and human-robot systems performance.