Epigenomics: From Chromatin Biology to Therapeutics

By Krishnarao Appasani

Book Overview

Understanding mechanisms of gene regulation that are independent of the DNA sequence itself - epigenetics - has the potential to overthrow long-held views on central topics in biology, such as the biology of disease or the evolution of species. High throughput technologies reveal epigenetic mechanisms at a genome-wide level, giving rise to epigenomics as a new discipline with a distinct set of research questions and methods. Leading experts from academia, the biotechnology and pharmaceutical industries explain the role of epigenomics in a wide range of contexts, covering basic chromatin biology, imprinting at a genome-wide level, and epigenomics in disease biology and epidemiology. Details on assays and sequencing technology serve as an up-to-date overview of the available technological tool kit. A reliable guide for newcomers to the field as well as experienced scientists, this is a unique resource for anyone interested in applying the power of twenty-first-century genomics to epigenetic studies.

• Format: Paperback
• Language: English
• ISBN: 1107697832
• ISBN13: 9781107697836
• Release Date: July 2014
• Publisher: Cambridge University Press
• Length: 574 Pages
• Weight: 1.99 lbs.
• Dimensions: 1.2" x 6.7" x 9.6"